[沙利文]：2024年活性胶原贴敷料研究报告 -尊龙凯时人生就博

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..................................................................................................3 1.1...................................................................................................3 1.1.1........................................................................................3 1.1.2........................................................................................4 1.2...............................................................................................8 1.2.1.............................................................................8 1.2.2....................................................................................9 ............................................................................................13 2.1......................................................................................13 2.1.1...................................................................13 2.1.2...................................................................14 2.1.3................................................................15 2.1.4................................................................16 ........................................................................................18 3.1...................................................................18 3.1.1............................................................18 3.1.2............................................................21 3.2..................................................................................22 3.2.1...........................................................................22 3.3..........................................26 1.1. 1.1.1. 胶原蛋白30% α αiiiiiiiiiiii 1.1.2. 28 α i col1a1 [α1(i)]2α2(i) 67nm col1a2 [α1(i)]3 ii col2a1 [α1(ii)]3 iii col3a1 [α1(iii)]3 α v col5a1 [α1(v)]2α2(v) )]9nm col5a2 [α1(v)α2(v)α3(v col5a3 [α1(v)]3 xi col11a1 [α1(xi)α2(xi)α3(x i)]v col11a2 xxiv col24a1 [α1(xxiv)3] 二十七 col27a1 [α1(xxvii)3] facit ix col9a1 [a1(ix)a2(ix)a3(ix)] ii col9a2col9a3 xii col12a1 [a1(xii)]3 i xiv col14a1 [a1(xiv)]3 iii xvi col16a1 a1(xvi) -1dii α facit xix col19a1 a1(xix) n- [a1(xix)]2[a1(xix)]3[a1(xix)]4[a1(xix)]5[a1(xix)]6 xx col20a1 a1(xx) xxii col22a1 a1(xxii) - iv col4a1 [a1(iv)]2a2(iv) col4a2 [a1(iv)]2a3(iv) col4a3 [a1(iv)]2a4(iv) col4a4 [a1(iv)]2a5(iv) col4a5 [a1(iv)]2a6(iv) vii col7a1 [a1(vii)]3 xviii col18a1 a1(十八) α macits xiii col13a1 a1(十三) 二十三 col23a1 a1(二十三) xxv col25a1 a1(xxv) r xxvi col26a1 a1(xxvi) xviii col18a1 a1(十八) xv col15a1 a1(xv) 二十八 col28a1 a1(二十八) 1.2. 1.2.1. 胶原相关✲crp 1.2.2. 1981fda 2009 1 2 zydermⅰⅰ ca(oh)2naoh 1.2.3. 1 , 2 3 , 4 , , , , 5 , , 6 (sal=10-6),, , 2.1. 2.1.1. 2.1.2. 2024 11 7 2.1.3. “ ” 2.1.4. 2022 1136 4161062 2026 31.9% 3.1. 3.1.1. 11 2024 / 202411400 2024 11 3% 7% 5% 33% 20% 32% 贴片敷料溶液 凝胶 膏状、油状冻干 其他 2024 11 40 / 2024 11 5% 三类医疗器械二类医疗器械 3.1.2. 11 2024 11 2015314100520163141290202031400402021314033420223140734202331406152023314123220233141576202331419572024314155020243141788 3.2. 3.2.1.  200420042640329 200411200511 20099 201212 a 2013320142  gb18280/iso11137 2016 2015 a () 60 2016 (i  20222024q3 2100 600 2024 q3 1 >600 2 a ~120 3 b ~90  20222024q33 2022 2023 2024 1 ~174,300 ~260,700 ~212,200 2 a ~112,500 ~162,000 ~160,200 3 b ~39,600 ~49,050 ~50,400 2022 2023 2024 1 ~134,900 ~177,400 ~138,400 2 a ~48,000 ~69,000 ~71,000 3 b ~16,000 ~24,000 ~25,000 3  20222024q3 2022 2023 2024 1 ~683,700 ~1,173,400 ~1,129,900 2 a ~250,000 ~360,000 ~356,000 3 b ~88,000 ~109,000 ~112,000 1000  20222024q3 3.3. “ ” 2002 “ 1. ” 2. 2024 10 32 21 10 863 3. “ ” “ ”“ ” 4. *  “ ”    * [1]�–henkelw,glanvillerw.基于i型和iii型胶原分子之间的共价交联：n-末端非螺旋区域在i(α)和iii(α)链间形成分子间交联中的作用。欧亚journalof生物化学,1982,122:205-213. [2]蔡莉,陈宇,门芳,张岩,陈维,郑晓,王海,张静,刘浩,赵博.不同组织来源胶原生物材料的物理性质比较研究.材料科学,2017,7(4):431-439. 注：姓名和单位可能需要根据实际情况进行调整。上述翻译中假设作者名字为笔名或化名，实际翻译时应使用正确的作者名字和单位。 [3]格罗姆科瓦-克埃帕，k.j.;puścion-jakubik，a.;markiewicz-zukowska，r.;socha，k.紫外辐射对皮肤光老化的影响——体外研究综述.《皮肤护理学杂志》2021,20,3427–3431.doi:10.1111/jocd.14033 [4]菲德勒,a.l.;布尔科,s.p.;罗卡斯,a.;希德,b.g.三重胶原螺旋——一种古老的蛋白质结构，使动物多细胞生物和组织进化成为可能。《细胞科学杂志》2018,131,jcs203950. [5]弗兰克,m.,阿布森,j.,瑞恩,b.,加尔姆,l.,马泽拉,j.,巴-托利耶,l.,吉内马特,x.(2015).col3a1基因变异类型与血管型埃勒斯-丹洛斯综合征的表型和严重程度相关。欧洲人类遗传学杂志,23,1657–1664. [6]刘x，吴h，伯恩尼m，克兰s，雅尼施r.（1997）.iii型胶原对于i型胶原纤维形成及正常心血管发育至关重要.美国国家科学院院刊，94（5），1852–1856. [7]kuivaniemih,trompg.typeiiicollagen(col3a1):geneandproteinstructure,tissuedistribution,andassociateddiseases.gene,707,151–171. [8]王c.,布里森b.k.,批吉马m.,李q.,萨库拉k.,韩b.,戈尔德伯格a.m.,刘x.s.,马尔科隆戈m.s.,内莫托-伊万莫托m.,山口m.,沃尔克s.w.,韩l.(2020).类iii胶原是调控关节软骨和半月板的胶原纤维结构和生物力学的关键调节因子。matrixbiology,85-86,47–67. [9]罗欣,d.,赖文,v.,拉吉瓦尔,d.k.(2023).组织损伤与再生中i型胶原和iii型胶原的调节.心脏病与心血管医学,7(1),5–16. 注[10：]r这o里dr假igu设e作s,者m.的,k名os字a是ric根,n据.,英bo文nh名a翻m,译c的.a，.,并&且gu“srtinegrh,”g翻.译c.为(2“罗01欣9)”.，w“oruani”d翻h译ea为lin“赖g:文a”c，e“llauglarrawpearl”s翻pe译ct为iv