iii ◼ iii202002iiiiii2014863iiiiiiiii —— collagen has been widely applied in cosmetic products for skin care benefits and beyond. most of those collagenmaterials are animal derived. apart from the most dominating type i collagen, other types including type iii, are farless prevalent, making extraction and purification extremely difficult and costly. a technology advancement such asprecision fermentation can be utilized to well address market pull for a non-animal derived collagen for cosmeticapplication. traditionally, animal by-products from the meat and fish industry have been the primary sources of collagen, withbovine, porcine, and marine collagen being the most commonly used types. however, these animal-derivedsources have several significant drawbacks. for instance, bovine collagen is associated with the risk of transmittingzoonotic diseases such as bse or foot and mouth disease. additionally, animal sources of collagen are notsustainable and the supply chains may be linked to deforestation and overfishing. furthermore, animal-derivedcollagens may not be acceptable to vegans or certain cultures. in contrast, recombinant collagen produced throughfermentation offers several advantages over animal-derived collagen, including improved sustainability, safety, andcultural acceptability. recombinant collagens through precision fermentation is a timely response to both the “market pull”: e.g. ethicalconsumerism: rising consumer interest in animal-free supply chains; increased focus on sustainable production anddecarbonization; and the “technology push”: precision fermentation revolutionize the production of such ingredientsusing synthetic biology methods, the whole market is observing significant momentum in recent years thanks tomassive vc funding as well as governmental grants and subsidies. when we have the bi-factor “market pull” plus“technology push”, it stresses out the needs from both sides for a solution such as recombinant collagen. ——anne yun mu, global head of applied innovationbioactivessegment, evonik ◼ iiiiii—— —— iii""2018iii2021 —— 2015 28%: —— ◼ iii 1.1-----------------------111.1.1-----------------------111.1.2-----------------------111.1.3-----------------------121.1.4-----------------------121.1.5-----------------------13 1.2.1iiijyc301——-----------------------141.2.2iiijyc301——-----------------------151.2.3iii-----------------------16 1.3iii—— iii 2.1iii-----------------------20 2.1.1-----------------------202.1.2iii-----------------------212.2iii——-----------------------232.3iii——-----------------------252.4iii——-----------------------262.5iii——-----------------------272.6iii/-----------------------282.6.1iii-----------------------282.6.2iii-----------------------29 2.7iii-----------------------302.7.1iiijyc301-----------------------302.7.2iiijyc301-----------------------312.7.2-----------------------31 iii 3.1iii-----------------------333.1.1-----------------------333.1.2-----------------------333.2iii——-----------------------383.3iii——-----------------------403.4iii——-----------------------413.5iii——-----------------------423.6iii/-----------------------433.6.1-----------------------433.6.2-----------------------443.7iii-----------------------453.7.1iiijyc301-----------------------453.7.2-----------------------46 iii 4.1iii-----------------------484.1.1-----------------------484.1.2iii-----------------------49 4.2iii——-----------------------514.3iii——-----------------------524.3.1iii-----------------------524.3.2iii-----------------------524.4iii3d-----------------------534.4.1 3d-----------------------534.4.2-----------------------534.5iii/-----------------------544.5.1iii/-----------------------544.5.2iii/-----------------------55 iii 5.1iii-----------------------57 5.1.1-----------------------575.1.2iii-----------------------585.2iii——-----------------------605.3iii——-----------------------625.4iii——-----------------------635.5iii/-----------------------645.5.1-----------------------645.5.2-----------------------655.6iii-----------------------665.6.1iiijyc301-----------------------665.6.2-----------------------66 iii 6.1iii-----------------------686.1.1-----------------------686.1.2iii-----------------------686.2iii——-----------------------716.3iii——-----------------------726.3.1iii-----------------------726.3.2iii-----------------------726.4iii/-----------------------736.5iii-----------------------746.5.1iiijyc301-----------------------746.5.2iiijyc301-----------------------75 iii iii 8.1iii-----------------------848.1.1-----------------------848.1.2-----------------------848.1.3iii-----------------------858.1.4iii-----------------------858.2iii-----------------------868.2.1-----------------------868.2.2-----------------------868.2.3-----------------------868.2.4-----------------------878.2.5iiijyc301-----------------------878.3iii-----------------------888.3.1-----------------------888.3.2iiijyc301-----------------------88 iii 9.1iii------